A unifying framework for amyloid-mediated membrane damage: The lipid-chaperone hypothesis
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics(2022)
摘要
Over the past thirty years, researchers have highlighted the role played by a class of proteins or polypeptides that forms pathogenic amyloid aggregates in vivo, including i) the amyloid Aβ peptide, which is known to form senile plaques in Alzheimer's disease; ii) α-synuclein, responsible for Lewy body formation in Parkinson's disease and iii) IAPP, which is the protein component of type 2 diabetes-associated islet amyloids. These proteins, known as intrinsically disordered proteins (IDPs), are present as highly dynamic conformational ensembles.
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关键词
Amyloid,Aggregation,Ion channel-like,Model membrane,Lipid-chaperone,Toxic oligomer
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