Mediastinal lymph node removal ameliorates cytotoxic T-lymphocyte functions in patients with non-small cell lung cancer.

Ayse Engin,Akif Turna,Fehim Esen,Melek Agkoc,Duygu Ilke Cikman,Omer Faruk Saglam,Gunnur Deniz,Esin Cetin Aktas

Tumori（2023）

Cited 3|Views7

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Abstract

CTLs in the MLNs and peripheral blood of the patients with NSCLC had an immunosenescent phenotype, increased immune checkpoint receptor expression, and impaired cytotoxicity. MLN removal by VAMLA improved these phenotypic and functional characteristics of CTLs. These changes may explain the potential contribution of VAMLA to improved survival.

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Key words

CTLA-4,Cytotoxic T cells,NSCLC,PD-1,VAMLA

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