Duration of cooling with water for thermal burns as a first aid intervention: A systematic review

•From 560 screened references, we included 4 studies. Out of 5978 patients, 2893 (48%) reported a cooling duration of ≥20 min•IWe found no association between duration of cooling and size/depth of burn, days to re-epithelialization or skin grafting.•Confidence in the estimate of effect, for the outcomes evaluated, was very low due to very serious risk of bias