Size does matter: piRNA and miRNA targeting
TRENDS IN BIOCHEMICAL SCIENCES（2022）
Abstract
Piwi-interacting RNAs (piRNAs) guide PIWI proteins to bind and cleave RNAs. Originally, piRNAs were described as a system for transposable element repression. Recently, Anzelon, Choudhury, Hughes et al. uncovered the structural basis for piRNA targeting, whereby they are recognized in a manner distinct from targeting by miRNAs.
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Key words
Argonaute,miRNA,piwi-interacting RNA,PIWI,RNA binding,targeting
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