The GG genotype of the serotonin 4 receptor genetic polymorphism, rs1345697, is associated with lower remission rates after antidepressant treatment: Findings from the METADAP cohort

Vianney Poinsignon,Romain Colle,Khalil El Asmar,Indira Mendez-David,Denis J David,Abd El Kader Ait Tayeb,Kenneth Chappell,Florence Gressier,Hugo Herrero,Bruno Fève,Laurent Becquemont,Emmanuelle Corruble,Céline Verstuyft

Journal of Affective Disorders（2022）

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摘要

•Serotonin 4 receptor (HTR4) genetic polymorphism association with remission in MDD.•Association between the HTR4 rs1345697 polymorphism and depressive symptoms improvement and remission after antidepressant treatment in naturalistic study.•A potential pharmacogenetics biomarker to improve outcome in patients with MDD.

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关键词

Pharmacogenetics,HTR4 polymorphism,Major depressive episode,Antidepressant,Remission

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