Exosomes from hypoxic pre-treated ADSCs attenuate acute ischemic stroke-induced brain injury via delivery of circ-Rps5 and promote M2 microglia/macrophage polarization

•Exosomes from hypoxic pre-treated ADSCs improve cognitive function.•Exosomes from hypoxic pre-treated ADSCs can delivery circ-Rps5.•SIRT7 and miR-124-3p are downstream targets of circ-Rps5.•Inhibit miR-124-3p/SIRT7 signal inhibit the protective effect of circ-Rps5.•Circ-Epc1-modified ADSC exosome improved cognitive function.