Isotopic labelling-based analysis elucidates biosynthesis pathways in Saccharomyces cerevisiae for Melatonin, Serotonin and Hydroxytyrosol formation

M Gallardo-Fernández, J Valls-Fonayet,E Valero,R Hornedo-Ortega,T Richard,A M Troncoso,M C Garcia-Parrilla

Food Chemistry（2022）

Cited 9|Views8

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Abstract

•Bioactive compounds are produced during alcoholic fermentation.•Yeasts can synthetize melatonin by different pathways: from tryptophan and serotonin.•Yeasts produce Hydroxytyrosol from labelled tyrosine and also from other sources.•Isotopic labelling proved useful as strategy to elucidate biosynthetic pathways.

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Key words

Yeast,Nitrogen,Indolic compounds,Polyphenol,Alcoholic fermentation,HRMS

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