31764 LRP1B expression is correlated with age and perineural invasion in metastatic cutaneous squamous cell carcinoma: A pilot study

Introduction: There are 1,000,000 cases of cutaneous squamous cell carcinoma (SCC) in the United States annually. While only 2-5% of SCCs metastasize, those that do have a poor prognosis. A recent study by our group demonstrated that LRP1B is mutated in 37% of SCCs, making it one of the top six genes mutated in SCC. However, the biologic significance of LRP1B mutations in SCC is unknown.