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Alkylidene Dihydropyridines Are Surrogates for Pyridylic Anions in the Conjugate Addition to ,-Unsaturated Ketones

Jiaqi Shi, Ashik Sayyad, Dan Fishlock, Arturo Orellana

Organic Letters(2022)

引用 6|浏览9
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摘要
We show that alkylidene dihydropyridines, readily prepared from 4-alkylpyridines, behave as soft nucleophiles toward a range of alpha,beta-unsaturated ketones under the influence of silyl Lewis acids to give the products of conjugate addition. In contrast to existing methods, which use strongly basic pyridylic anions, this reaction tolerates a wide array of functional groups, providing access to useful heterocyclic scaffolds.
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关键词
alkylidene dihydropyridines,pyridylic anions,ketones,conjugate addition
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