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Duo Shared Genomic Segment analysis identifies a genome-wide significant risk locus at 18q21.33 in myeloma pedigrees.

Rosalie Griffin Waller,Michael J Madsen,John Gardner,Douglas W Sborov,Nicola J Camp

Journal of translational genetics and genomics（2021）

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Abstract
Our results provide novel risk loci with segregating evidence from multiple HRPs and offer compelling targets and specific segment carriers to focus a future search for functional variants involved in inherited risk formyeloma.
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Key words
High-risk pedigrees,disease susceptibility,gene mapping,multiple myeloma
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