Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA
FUTURE VIROLOGY(2022)
Abstract
While tolerance to COVID-19 vaccination is considered satisfactory, a phenomenon of myocarditis, although rare, is becoming a safety concern in mRNA COVID-19 vaccination. The presence of low residual levels of double-strand RNA (dsRNA) has been reported in mRNA COVID-19 vaccine preparations. dsRNA is a known inducer of immune-inflammatory reactions. dsRNA present in vaccine nanoparticles may be suspected to be at the origin of the still unexplained cases of myocarditis.
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Key words
COVID-19, dsRNA, mRNA COVID-19 vaccines, myocarditis
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