The Effects of Stimulation with PMA/Ionomycin on CD4+ T Cell Proliferation and Surface CD4 Molecule Modulation of Patients with LRBA Deficiency and CVID with the Unsolved Genetic Defect.

Fereshte Salami,Sahar Shariati,Seyed Erfan Rasouli,Samaneh Delavari,Marzieh Tavakol,Homa Sadri,Babak Asghari,Reza Yazdani,Nima Rezaei,Hassan Abolhassani,Gholamreza Azizi

Endocrine, metabolic & immune disorders drug targets（2022）

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摘要

Despite the reported decrease in CD4+ T cell frequency in patients with CVID and LRBA deficiency, our findings demonstrated that their CD4+ T cells have a normal proliferative response to stimuli similar to healthy individuals.

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关键词

CD4+ T cell,Common variable immunodeficiency,LRBA deficiency,primary immunodeficiencies,proliferation,stimulation

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