A comprehensive bioinformatic analysis of RanBP9 expression and the relation to prognosis in human breast cancer

Aim: To explore the role of RanBP9 in breast cancer. Materials & methods: Oncomine, TIMER, GEPIA, UALCAN, c-BioPortal databases and tissue microarray analysis were used in this study. Results: The expression level of RanBP9 is elevated in breast cancer tissues, which is associated with poor prognosis in breast cancer patients. RanBP9 exhibits genetic alterations and a decreased methylation level in cancer tissues. RanBP9 may also regulate cell cycle progression and is linked to tumor purity and the infiltrating levels of immune cells. Conclusions: RanBP9 may correlate with prognosis and immune infiltration in breast cancer, laying the foundation for future studies on the potential role of RanBP9 in breast cancer. Lay abstract RanBP9 has diverse function in various tumor types. However, the role of RanBP9 in breast cancer remains to be explored. In this study, we investigated the gene expression of RanBP9 using databases and clinical samples. We found the expression level of RanBP9 is raised in breast cancer tissues and is associated with poor prognosis for breast cancer patients. RanBP9 may be involved in the regulation of the cell cycle and related to tumor immunity. Overall, we found that RanBP9 may correlate with prognosis and immune infiltration of breast cancer, laying the foundation for future studies on the potential role of RanBP9 in breast cancer.