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Graded Administration of Second Dose of Moderna and Pfizer-BioNTech COVID-19 mRNA Vaccines in Patients With Hypersensitivity to First Dose

Linh-An C. Tuong,Peter Capucilli,Mary Staicu,Allison Ramsey,Edward E. Walsh,S. Shahzad Mustafa

OPEN FORUM INFECTIOUS DISEASES（2021）

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Abstract
Two mRNA coronavirus disease 2019 (COVID-19) vaccines, Moderna and Pfizer-BioNTech, require 2 doses for maximum efficacy. This case series reports the safety and immunogenicity of a graded administration of the second dose of the Moderna and Pfizer-BioNTech COVID-19 vaccines in patients with immediate hypersensitivity reactions to the first dose.
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Key words
COVID-19,graded administration,mRNA vaccine,SARS-CoV-2 spike protein
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