Changes in cytokine levels in breast cancer patients with CRCI before or after CALM intervention

To investigate the changes in cytokine (interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha) and interleukin 4 (IL-4)) levels and cognitive function before and after managing cancer and living meaningfully (CALM) intervention, in early-stage breast cancer patients with chemotherapy-related cognitive impairment (CRCI). One hundred and twenty-eight breast cancer patients with CRCI enrolled in this study, there are fifty patients underwent with 6 CALM interventions and seventy-eight patient care as usual (CAU). Cytokine (IL-1 beta, TNF-alpha and IL-4) levels in the patients were assessed, and the patients were evaluated with the Mini-Mental State Examination (MMSE), Prospective Memory (PM) and Retrospective Memory (RM), and Quality-of-life (QOL) and Psychological Distress Thermometer (DT) assessments before CALM intervention (BCM), after CALM intervention (ACM) and care of usual (CAU). Measures at these two time points and two groups were compared. There were significant differences in the performance on the RM, PM, MMSE, QOL and DT measures after, compared to before (t=8.126, t=8.007, t=-10.789, t=9.236, t=17.649, respectively; P<0.05), the CALM intervention, compared to CAU (t=-7.408, t=-7.300, t=8.128, t=-8.851, t=-10.572, respectively; P<0.05). In addition, cytokine levels, including IL-1 beta, TNF-alpha and IL-4, were significantly different before and after the CALM intervention (t=5.073, t=4.228, t=5.815, respectively; P<0.05) and the two groups (ACM vs CAU) were distinctly different (t=-3.353, t=-2.694, t=-3.268, respectively; P<0.05). furthermore, the cytokine levels (IL-1 beta, TNF-alpha and IL-4) have linear correlation with cognitive function before and after CALM intervention (r=-0.343/r=0.538, r=-0.375/r=-0.330, r=-0.310/r=-0.541, respectively; P<0.05). The present results indicated that CALM intervention could alleviate CRCI and that this process is accompanied by changes in IL-1 beta, TNF-alpha and IL-4 levels. These results further confirm that cytokines may be involved in CRCI and that CALM may become an efficient method to relieve CRCI-related symptoms in breast cancer patients.