Shared genetic influences on depression and menopause symptoms.

Joeri J Meijsen,Hanyang Shen,Mytilee Vemuri,Natalie L Rasgon,Karestan C Koenen, Laramie E Duncan

Psychological medicine（2021）

引用 9|浏览8

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摘要

These results suggest that menopause symptoms have a complex genetic etiology which is partially shared with genetic influences on depression. Moreover, the TACR3 gene identified here has direct clinical relevance; antagonists for the neurokinin 3 receptor (coded for by TACR3) are effective treatments for hot flashes.

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关键词

Depression,GWAS,PTSD,estrogen,genetic correlation,hormone replacement therapy,hormone therapy,menopause,progestogen,vasomotor symptoms

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