Combined adjuvant effects of ambient vapor-phase organic components and particulate matter potently promote allergic sensitization and Th2-skewing cytokine and chemokine milieux in mice: The importance of mechanistic multi-pollutant research

Toxicology Letters(2022)

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摘要
•Vapor- and particle-phase air pollutants each enhance allergic sensitization.•Concurrent exposure to vapor and particles results in aggravated adjuvant effects.•Combined adjuvant effects of vapor and particles induces more robust allergic lung inflammation.•Co-exposure to vapor and particles creates a Th2-skewing milieu in the lungs of sensitized mice.
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关键词
BAL,BALF,CYP1A1,DC,HO-1,LPS,MBP,Nrf2,OVA,PAH,PM,RT-PCR,Th1,Th2,Treg,VPOP,YM1
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