Crosslinked Polypeptide Films via RAFT-Mediated Continuous Assembly of Polymers
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2022)
摘要
Polypeptide coatings are a cornerstone in the field of surface modification due to their widespread biological potential. As their properties are dictated by their structural features, subsequent control thereof using unique fabrication strategies is important. Herein, we report a facile method of precisely creating densely crosslinked polypeptide films with unusually high random coil content through continuous assembly polymerization via reversible addition-fragmentation chain transfer (CAP-RAFT). CAP-RAFT was fundamentally investigated using methacrylated poly-L-lysine (PLLMA) and methacrylated poly-L-glutamic acid (PLGMA). Careful technique refinement resulted in films up to 36.1 +/- 1.1 nm thick which could be increased to 94.9 +/- 8.2 nm after using this strategy multiple times. PUMA and PLGMA films were found to have 30-50% random coil conformations. Degradation by enzymes present during wound healing reveals potential for applications in drug delivery and tissue engineering.
更多查看译文
关键词
CAP-RAFT, Crosslinked, Polypeptide, Surface-initiated polymerization, Secondary structure
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要