Kidney transplantation from SARS-CoV-2-positive deceased donor

AMERICAN JOURNAL OF TRANSPLANTATION(2022)

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摘要
To expand the available donor pool, many organ procurement organizations and transplant programs have begun to consider severe acute respiratory syndrome coronavirus(SARS-CoV-2) nucleic acid test positive candidates(1). It is becoming increasingly clear that not all donors with a positive nucleic acid amplification test for SARS-CoV-2 are contagious, and some of these organs can be transplanted with careful selection(2, 3). Data from 31 kidney transplants from living donors with resolved COVID-19 in India showed the safety of this approach(4). However, it is unknown whether kidneys from donors with active COVID-19 can also be safely transplanted(3, 5). Beyond the "active" infection designation, it is clinically possible to risk stratify donors with COVID-19 based on additional parameters such as clinical history and radiologic or laboratory findings. Here we present a case and 210-day outcome of a successful kidney transplantation from otherwise medically suitable SARS-CoV-2 PCR positive deceased donors.
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关键词
clinical research, practice, donors and donation, donation after circulatory death (DCD), donors and donation, extended criteria, infectious disease, kidney transplantation, nephrology, organ procurement and allocation, Organ Procurement and Transplantation Network (OPTN)
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