New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis

Wei Sun,William A T Raimbach,Luke D Elliott,Kevin I Booker-Milburn,David C Harrowven

CHEMICAL COMMUNICATIONS（2022）

引用 12|浏览5

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摘要

An oxidative photocyclisation of N-arylenaminones to indoles is described, that mirrors the Fischer indole synthesis but uses anilines in place of arylhydrazines. Its value is exemplified with new approaches to the WHO-listed APIs ondansetron and alosetron.

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