Mini-review: Dissecting receptor-mediated stimulation of TRPV4 in nociceptive and inflammatory pathways

Scott Peng,Daniel P Poole,Nicholas A Veldhuis

Neuroscience Letters（2022）

引用 7|浏览4

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摘要

•TRPV4 is an ion channel that integrates signaling by other cell surface receptors, including those from the GPCR family.•Lipid metabolites are central to this polymodal gating behavior.•New insights have revealed how these pathways converge on TRPV4 to influence pain and inflammation.

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关键词

TRP ion channel,GPCR,Phospholipase,Eicosanoids,Nociception,Neurogenic inflammation

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