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The screening value of RT-LAMP and RT-PCR in the diagnosis of COVID-19: systematic review and meta-analysis

Ruiyang Pu,Sha Liu,Xiaoyu Ren,Dian Shi,Yupei Ba,Yanbei Huo,Wenling Zhang,Lingling Ma,Yanyan Liu, Yan Yang,Ning Cheng

Journal of Virological Methods（2022）

Cited 56|Views24
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Abstract
•RT-PCR and RT-LAMP are widely used; however false negative rate (FNR) are 6% ∼ 12 %.•Sensitivity and FNR of index test were significantly affected by the reference method.•PCR is not the perfect gold standard for comparison of diagnostic accuracy with COVID-19.•Performance of RT-LAMP may be exaggerated when RT-PCR is used as reference.
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COVID-19,Diagnostic accuracy,RT-PCR,RT-LAMP,False-negative rate
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