The Allantois and Urachus: Histological Study Using Human Embryo and Fetuses

Introduction: Relatively little is known about allantois and urachal development in early humans. Design: Serial sagittal histological sections from eight human embryos and fetuses were examined to determine allantois development. Results: At gestational age 6-7 weeks, the primitive allantois consists of an enlarged tube located between the umbilical cord and abdominal cavity, whereas the urachus is not yet developed. At 8 weeks, the allantois gradually withdraws from the distal to the proximal end of the umbilical cord, and both the proximal allantois and the rectum (hindgut) start to develop into the cloaca. At 10 weeks, the allantois was located mostly in the abdominal cavity. Conclusion: The urachus forms from the distal end of the allantois and develops into a closed fibrous cord between the base of the urinary bladder and the umbilicus. The urogenital sinus forms from the proximal end of the allantois.