Longitudinal humoral response after SARS-CoV-2 vaccination in ocrelizumab treated MS patients: To wait and repopulate?

Z L E van Kempen, L Wieske, E W Stalman, L Y L Kummer,P J van Dam, A G Volkers,L Boekel,A A Toorop,E M M Strijbis, S W Tas,G J Wolbink,M Löwenberg,C van Sandt,A Ten Brinke,N J M Verstegen, M Steenhuis, T W Kuijpers,S M van Ham,T Rispens,F Eftimov,J Killestein

Multiple Sclerosis and Related Disorders（2022）

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摘要

Low B-cell counts prior to vaccination and shorter time between OCR infusion and vaccination may negatively influence humoral response but does not preclude seroconversion. We advise OCR treated patients to get their first vaccination as soon as possible. In case of an additional booster vaccination, timing of vaccination based on B-cell count and time after last infusion may be considered.

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MS,OCR,DMT

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