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Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics

Stephan M. Tirier,Jan-Philipp Mallm,Simon Steiger,Alexandra M. Poos,Mohamed H. S. Awwad,Nicola Giesen,Nicola Casiraghi,Hana Susak,Katharina Bauer,Anja Baumann,Lukas John,Anja Seckinger,Dirk Hose,Carsten Müller-Tidow,Hartmut Goldschmidt,Oliver Stegle,Michael Hundemer,Niels Weinhold,Marc S. Raab,Karsten Rippe

NATURE COMMUNICATIONS（2021）

Cited 40|Views32
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Abstract
Relapsed/refractory multiple myeloma (RRMM) is characterized by a remarkable heterogeneity and high drug resistance. Here, the authors analyse RRMM samples by single-cell RNA-sequencing, revealing molecular features associated with high-risk chromosomal 1q-gain and changes in the tumor microenvironment.
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Key words
Cancer microenvironment,Myeloma,Transcriptomics,Science,Humanities and Social Sciences,multidisciplinary
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