A highly sensitive and rapid LC-MS/MS method for quantification of bexarotene in mouse plasma and brain tissue: Application to mice pharmacokinetic study

•First report for quantification of bexarotene in biological matrix by LC–MS/MS.•LLOQ of 10.0 ng/mL was achieved with consumption of only 20 μL of plasma or tissue homogenate.•Simple sample pretreatment with a single-step protein precipitation method was employed.•First investigation of bexarotene pharmacokinetics in mice using a fully validated LC–MS/MS method.