Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming
FRONTIERS IN NEUROLOGY(2021)
Abstract
Objectives: Deep brain stimulation (DBS) programming is based on clinical response testing. Our clinical pilot trial assessed the feasibility of image-guided programing using software depicting the lead location in a patient-specific anatomical model.Methods: Parkinson's disease patients with subthalamic nucleus-DBS were randomly assigned to standard clinical-based programming (CBP) or anatomical-based (imaging-guided) programming (ABP) in an 8-week crossover trial. Programming characteristics and clinical outcomes were evaluated.Results: In 10 patients, both programs led to similar motor symptom control (MDS-UPDRS III) after 4 weeks (medicationOFF/stimulationON; CPB: 18.27 +/- 9.23; ABP: 18.37 +/- 6.66). Stimulation settings were not significantly different, apart from higher frequency in the baseline program than CBP (p = 0.01) or ABP (p = 0.003). Time spent in a program was not significantly different (CBP: 86.1 +/- 29.82%, ABP: 88.6 +/- 29.0%). Programing time was significantly shorter (p = 0.039) with ABP (19.78 +/- 5.86 min) than CBP (45.22 +/- 18.32).Conclusion: Image-guided DBS programming in PD patients drastically reduces programming time without compromising symptom control and patient satisfaction in this small feasibility trial.
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Key words
directional deep brain stimulation,image-guided programming,subthalamic nucleus,chronic stimulation,randomized controlled double-blind study,Parkinson's disease
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