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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

Diego F Coutinho,Prabhjot S Mundi,Lianna J Marks,Chelsey Burke,Michael V Ortiz,Daniel Diolaiti, Lauren Bird,Kelly L Vallance,Glorymar Ibáñez,Daoqi You,Matthew Long,Nestor Rosales,Adina Grunn,Andoyo Ndengu,Armaan Siddiquee,Ervin S Gaviria,Allison R Rainey,Ladan Fazlollahi,Hajime Hosoi,Andrea Califano,Andrew L Kung,Filemon S Dela Cruz

Med（2022）

Cited 5|Views18
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Abstract
•A network-based algorithm identifies molecular vulnerabilities in pediatric tumors•Pediatric renal tumors exhibit aberrant activation of exportin 1 (XPO1)•Inhibiting XPO1 in pediatric renal tumor models induces cell-cycle arrest and apoptosis•Selinexor has anti-tumor effect in PDX models and leads to disease control in a patient
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Key words
selinexor,eltanexor,malignant rhabdoid tumors,Wilms tumors,precision medicine,patient-derived xenograft model,PDX,exportin 1
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