METTL3/14 and IL-17 signaling contribute to CEBPA-DT enhanced oral cancer cisplatin resistance.

Xue Qiao,Li Zhu,Rongbo Song,Chao Shang,Yan Guo

Oral diseases（2023）

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摘要

Our results suggest that CEBPA-DT might regulate OSCC chemoresistance through BHLHB9 gene manipulated by METTL3/METTL14 as well as through IL-17 signaling inhibition, which may contribute to the assessment of potential therapeutic targets in OSCC chemoresistance.

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关键词

CEBPA-DT,IL-17 signaling,METTL3/14,RNA methylation,cisplatin,immune infiltration

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