Epidermal growth factor receptor exon 20 insertion variants in non-small cell lung cancer patients

Umberto Malapelle,Sara Pilotto,Maria Lucia Reale,Francesco Passiglia,Pasquale Pisapia,Francesco Pepe,Lorenzo Belluomini,Domenico Galetta,Diego Cortinovis,Marcello Tiseo,Antonio Passaro,Davide Seminati,Fabio Pagni,Hector Soto Parra,Maria Rita Migliorino,Danilo Rocco,Giancarlo Troncone,Silvia Novello

Critical Reviews in Oncology/Hematology（2022）

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摘要

•EGFR exon 20 insertions occur in about 1.5–3.0 % of NSCLC.•NGS technology is the best option to detect EGFR exon 20 insertions.•Chemotherapy still represents the current standard of care.•Promising new EGFR TKIs and bispecific antibodies are under evaluation.

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关键词

NSCLC,EGFR,Exon 20 insertions,NGS,Target therapy

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