Immunosuppressive activity of a cycloartane triterpene glycoside from Beesia calthaefolia by inhibiting T cell proliferation

Li-Hua Mu, Qiong Wang,Jin-Yuan Zhao,Ping Liu,Yuan Hu

International Immunopharmacology（2021）

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摘要

•BC-1 inhibited CD69 and CD25 expressions of mAbs-stimulated CD3+ T cells.•BC-1 significantly decreased the ratio of CD4+/CD8+.•BC-1 decreased IFN-γ, IL-2, IL-4 and IL-10 levels of mAbs-stimulated CD4+ T cells.•BC-1 inhibited mAbs-induced CD4+ T cell proliferation by ERK, JNK, PI3K/Akt pathways.

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关键词

Beesia calthaefolia,Cycloartane triterpene glycoside,Immunosuppressant,Purified T lymphocytes,PI3K/AKT,MARK/ERK

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