A new method to reduce allergenicity by improving the functional properties of soybean 7S protein through covalent modification with polyphenols

•A new method is proposed to reduce allergenicity of the soybean 7S Protein.•Conjugation with polyphenols reduced the allergenicity of the 7S protein in vitro and vivo.•Conjugation with polyphenols might mask or destroy epitopes on the 7S protein.•Conjugation with polyphenols enhanced certain functional properties of the 7S protein.