A GC × GC Tier α combustor operability prescreening method for sustainable aviation fuel candidates

•A Tier α (<1 mL) Sustainable Aviation Fuel prescreening process is reported.•Eight critical properties are predicted with uncertainty quantification.•Predictions leverage GC × GC data and a 1226 hydrocarbon database of compounds.•Predictions are evaluated against experimental measurements of 20 SAFs.•Uncertainty quantification approximates the variance from novel molecules.