The Diagnostic Role Of F-18-Choline, F-18-Fluciclovine And F-18-Psma Pet/Ct In The Detection Of Prostate Cancer With Biochemical Recurrence: A Meta-Analysis

Background Diagnosing the biochemical recurrence (BCR) of prostate cancer (PCa) is a clinical challenge, and early detection of BCR can help patients receive optimal treatment. We conducted a meta-analysis to define the diagnostic accuracy of PET/CT using F-18-labeled choline, fluciclovine, and prostate-specific membrane antigen (PSMA) in patients with BCR. Methods Multiple databases were searched until March 30, 2021. We included studies investigating the diagnostic accuracy of F-18-choline, F-18-fluciclovine, and F-18-PSMA PET/CT in patients with BCR. The pooled sensitivity, specificity, and detection rate of F-18-labeled tracers were calculated with a random-effects model. Results A total of 46 studies met the included criteria; 17, 16, and 13 studies focused on F-18-choline, fluciclovine, and PSMA, respectively. The pooled sensitivities of F-18-choline and F-18-fluciclovine were 0.93 (95% CI, 0.85-0.98) and 0.80 (95% CI, 0.65-0.897), and the specificities were 0.91 (95% CI, 0.73-0.97) and 0.66 (95% CI, 0.50-0.79), respectively. The pooled detection rates of F-18-labeled choline, fluciclovine and PSMA were 66, 74, and 83%, respectively. Moreover, the detection rates of F-18-labeled choline, fluciclovine, and PSMA were 35, 23, and 58% for a PSA level less than 0.5 ng/ml; 41, 46, and 75% for a PSA level of 0.5-0.99 ng/ml; 62, 57, and 86% for a PSA level of 1.0-1.99 ng/ml; 80, 92, and 94% for a PSA level more than 2.0 ng/ml. Conclusion These three F-18-labeled tracers are promising for detecting BCR in prostate cancer patients, with F-18-choline showing superior diagnostic accuracy. In addition, the much higher detection rates of F-18-PSMA showed its superiority over other tracers, particularly in low PSA levels. Systematic Review Registration PROSPERO, identifier CRD42020212531.