Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy

Si Li,Nishant Sharma,Daniel Kazmierski, Mohammad Asim Amjad,Yishan Dong,Yichen Wang,Namita Sharma,Srinivasarao Ramakrishna,Pius Ochieng

CUREUS（2021）

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摘要

Immune checkpoint blockade is a rapidly expanding therapeutic modality in oncology. However, its adverse effects extend beyond the cytotoxicity of conventional chemotherapy. Pneumotoxicity associated with immune checkpoint therapy presents a diagnostic conundrum that has been further complicated by the COVID-19 pandemic. We report a case of a patient with metastatic urothelial carcinoma who developed diffuse alveolar hemorrhage (DAH) following treatment with avelumab.

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关键词

immune check-point inhibitor,diffuse alveolar hemorrage,urothelial malignancy,acute hypoxemic respiratory failure,ground-glass opacity

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