Investigation of histological heterogeneity based on the discrepancy between the hyperintense area on T2-weighted images and the accumulation area on 11C-methionine PET in minimally enhancing glioma

•Low grade glioma that shows hyper intense area on T2 weighted MRI or FLAIR imaging.•MET-PET reflects the extent of glioma cell invasion, but does not coincide with MRI.•The pathological heterogeneity may reflect the images discrepancy of MET-PET and MRI.•The understanding of this relevance is useful for correct diagnosis and surgical planning.