Comparison Of The Application Value Of Cycloserine And Linezolid In The Treatment Of Multi-Drug Resistant Pulmonary Tuberculosis

To explore the application value of cycloserine and linezolid in treating the multi-drug resistant pulmonary tuberculosis and their influence on the neurological function of patients. From August 2016 to May 2017, 179 patients with multi-drug resistant pulmonary tuberculosis treated in Wuhan Jinyintan Hospital were collected, including 65 patients treated with linezolid (LZ) in the LZ group, 61 patients treated with cycloserine (CS) in the CS group and 53 patients received conventional treatment in the routine treatment group (RTG). The sputum negative conversion rate, lesion absorption, cavity reduction, neurological adverse reactions and SF-36 score of patients were observed in the three groups. Independent risk factors of sputum not turning negative were analyzed. ROC was used to test the predictive value of independent risk factors. The sputum negative conversion rate, lesion absorption rate and cavity reduction rate in the LZ group and CS group were higher than those in the RTG after treatment for 18 months and 24 months. At the 24th month, the sputum negative conversion rate, lesion absorption rate and cavity reduction rate in the CS group were higher than those in the LZ group. The incidence rate of neurological adverse reactions in the CS group was higher than that in the LZ group and RTG (P<0.05). SF-36 in the CS group was lower than that in the LZ group and RTG (P<0.05), and SF-36 in the LZ group was significantly higher than that in the RTG (P<0.05). Age, course and number of previous anti-tuberculosis treatment were independent risk factors for patients not turning negative. The ROC curve showed that the area under the age curve was 0.790, the area under the disease course curve was 0.632, and the area under the number of previous anti-tuberculosis curve was 0.586. CS was better than LZ in treating the multi-drug resistant pulmonary tuberculosis, but LZ had less adverse effects on neurological function than CS.