Changes In Galectin-3 Levels And Left Ventricular Systolic Function In Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention

Purpose: This study aimed to explore the relevance of changes in Galectin-3 (Gal-3) levels and left ventricular systolic function of patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: This study selected 82 ACS patients who were admitted into our hospital for PCI treatment from Aug 2018 to Aug 2019 as candidates. Also, this study chose 82 healthy people after their hospital physical examination as the normal group. The study utilized quantitative enzyme-linked immunosorbent assay (ELISA) to test the serum Gal-3 level of patients. The study also utilizes multiple logistic regression to analyze the Gal-3 relationship with the left ventricular function of ACS patients after PCI. Results: The univariate analysis revealed that gender, age, smoking history, drinking history, systolic blood pressure, diastolic blood pressure, cardiac function classification, total cholesterol amount, blood creatinine, triglyceride, fasting blood glucose, diabetes and hypertension between these two groups showed no statistically significant difference (P > 0.05). The Gal-3 level and NT-pro BNP levels of patients after PCI were lower than in patients before PCI, which had a statistically significant difference (P < 0.05). The comparison of hs-CRP levels in patients between both groups showed no statistical difference (P > 0.05). There was no statistically significant difference in the diameter of the left atrium, CO and SV before and after PCI (P > 0.05). The LVEDD and LVESD level of patients after PCI were lower than before PCI, with a statistically significant difference (P < 0.05). The results of Pearson correlation analysis revealed that Gal-3 level has a positive correlation with LVEDD (r = 0.721, P < 0.05) and a negative correlation with LVEF (r = 0.607, P < 0.05). Conclusion: There is a close relationship between the change of Gal-3 level and ventricular systolic function. Therefore this index can be clinically used for early diagnoses and disease treatment.