Interleukin-18 Is A Sensitive Marker Of Flare Initiation In Adamantiades-Behcet Disease

Adamantiades-Behçet's disease (ABD; MIM 109650) is a rare, neutrophilic vascular reaction or vasculitis with a chronic recurrent progressive course leading to systemic inflammatory vascular disease with potentially severe prognosis. Its aetiology remains unknown. A genetic predisposition, triggered by infection/environmental factor(s) leading to hyperergic immunological reaction/damage of the vascular endothelium is assumed. A responsible gene locus is probably located on chromosome 6 short arm (6p21.3) inside the major histocompatibility complex area.