Nitrogen-doped MoS2 QDs as fluorescent probes for sequential dual-target detection and their microfluidic logic gate operations
Microchemical Journal(2021)
摘要
Fluorescence sensors show great potential as molecular logic gates to sensitively detect different analytes in trace level. For achieving multi-target analysis, it is desirable for developing complex molecular logic gates by using multi-target fluorescence sensing system. Herein, novel nitrogen-doped molybdenum disulfide quantum dots (MoS2 QDs) have been synthesized and designed as the fluorescent probes for dual-target detection and microfluidic logic gate operations. Nitrogen-doped MoS2 QDs exhibit fluorescence "on-off-on" characteristics by sequential addition of Fe3+ ions and ascorbic acid (AA). The controllably modulating dispersion or aggregation state of nitrogen-doped MoS2 QDs is successfully obtained by addition of Fe3+ or/and AA. The static quenching mechanism of between nitrogen-doped MoS2 QDs and Fe3+ ions is illustrated in detail. This dual-target fluorescence sensor exhibited good sensitivity and selectivity to Fe3+ and AA, and the limit of detection values were 11 mu M and 960 nM, respectively. Inspired by these results, nitrogen-doped MoS2 QDs-based "IMPLY" logic gate is fabricated for intelligent fluorescent sensing of Fe3+ and AA. More importantly, using blue fluorescence of nitrogen-doped MoS2 QDs, fluorescent "IMPLY" logic gate integrating with microfluidic chip is constructed for visually discriminating Fe3+ or/and AA with the naked eyes, which has the advantages of microliter reagent consumption, automated operation and visible readout. This "visible-invisible-visible" photoluminescence property of nitrogen-doped MoS2 QDs and their microfluidic logic gate operations provide a novel strategy for dual-target sensing.
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关键词
Dual-target sensing,Ascorbic acid,Logic gate,Microfluidic chip,MoS2 quantum dots,Fe3+ ion
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