Meta-Analysis of Cell Type-Specific DNA Methylation of Childhood Attention-Deficit/Hyperactivity Disorder Symptoms

Mandy Meijer,Marieke Klein,Doretta Caramaschi,Rosa Mulder, Marta Cosin,Xueling Lu,Yining Zhang,Stefan Roeder,Lea Zilich,Anke Huels,Catharina Hartman,Harro Snieder,Mariona Bustamante,Gunda Herberth,Barbara Franke,Bill Copeland,Karolina Aberg,Edwin van den Oord

EUROPEAN NEUROPSYCHOPHARMACOLOGY（2022）

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摘要

The interplay of genetic factors and environmental adversities in ADHD can be reflected by cell type-specific DNA methylation (DNAm). Previous methylome-wide association studies (MWAS) for ADHD have been performed in bulk tissue only, where meaningful DNAm signal could be left undetected. We aim to identify cell type-specific DNAm profiles associated with childhood ADHD symptoms.

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关键词

Epigenetics, ADHD, Cell Type Specific EWAS

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