Numerical Simulation Analysis And Structural Optimization Design Of Microspheres Prepared By A High-Pressure Homogenizer

To realize the controlled mass production of microspheres prepared by a high-pressure homogenizer and solve the problem of protein structure damage caused by very high pressure and overheating. This study established a numerical model based on the high-pressure homogenizer and performed simulation calculations using computational fluid dynamics (CFD). Through multipressure gradient microsphere preparation experiments, the particle size obtained by experiment and numerical calculation were compared and analyzed. According to the principle of conservation of energy, the speed was established as the optimization reference target, the structure of homogenizer was optimized and designed, and the corner spacing, corner radian, and corner taper of the homogeneous cavity were determined as the optimization objects. The ternary and cubic relationship equations of the optimized structure were fitted, and the continuous optimization of multi factor relations were realized. The results show that the optimal structural parameters are 0.496 mm corner spacing, 0.493 mm corner radian and 1.86 degrees corner taper, the fluid motion velocity of the high-pressure homogenizer increases from 234 m/ s to 297 m/s under 30 MPa, and the velocity increases by 26.9%, and the particle size of the microsphere reaches the treatment effect of 50 MPa. The increase in kinetic energy indicates that the friction is overcome, the heat generation is reduced. The research has solved the problems of high pressure and overheating encountered in the process of homogeneous production, realized the social needs of efficient and green production, and provided support for the further development of homogenizer technology.