Assessment Of Bleomycin Pulmonary Toxicity In Men With Poor-Prognosis Non-Seminomatous Germ-Cell Tumors Treated In The Getug 13 Phase Iii Trial
ANNALS OF ONCOLOGY(2021)
Abstract
In 2014, the GETUG 13 trial has established the role of early intensified treatment for men with poor prognosis germ-cell tumors (GCT) and unfavorable tumor marker decline (Fizazi K, Lancet Oncol 2014). Patients with unfavorable marker decline were randomized after 1 cycle of BEP to receive either 3 additional BEP or dose-dense chemotherapy with personalized cumulative doses of bleomycin (potentially exceeding the 300 mg recommended threshold) based on serial lung function assessments. We assessed pulmonary toxicity of this strategy.
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Key words
bleomycin,pulmonary toxicity,tumors,poor-prognosis,non-seminomatous,germ-cell
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