Mutational Landscape Of Large Cell Neuroendocrine Lung Carcinoma: Molecular Characterization Using Next Generation Sequencing

M. San Roman-Gil, L. Sanz-Gomez, J. Chamorro-Perez,Y. Lage, M. E. O. Garcia,A. Gomez,E. Corral De La Fuente, D. I. Rosero-Rodriguez,V. Albarran Fernandez,J. Pozas, P. Alvarez-Ballesteros, E. M. Vida-Navas, J. J. Soto-Castillo,J. Torres-Jimenez,J. Esteban-Villarrubia, I. Orejana-Martin,A. Benito Berlinches,P. Garrido Lopez

ANNALS OF ONCOLOGY(2021)

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摘要
Large cell neuroendocrine lung carcinoma (LCNEC) is an aggressive subtype with an incidence around 3% of all lung cancer. The treatment approach for advanced patients remains controversial due to the lack of large randomized trials including this subtype. Owing to this fact, molecular characterization using next generation sequencing (NGS) technology has become a key tool for the molecular profiling of LCNEC.
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lung carcinoma
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