Tmprss2-Erg Expression And Clinical Evolution Of Metastatic Hormone Sensitive Prostate Cancer

C. Aversa,N. Jimenez,M. Marin-Aguilera,L. Ferrer,L. Rodriguez-Carunchio,S. Diaz-Mercedes,A. Font Pous,A. Rodriguez-Vida,M. Domenech Santasusana,M. Figols Gorina,M. A. Climent Duran,S. Cros Costa,I. Chirivella,D. Herrero Rivera,E. Gonzalez-Billalabeitia, D. Jimenez-Peralta,J. Carles Galceran,C. Suarez Rodriguez,O. Reig Torras,B. Mellado

ANNALS OF ONCOLOGY（2021）

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摘要

TMPRSS2-ERG gene fusion is the most frequent alteration in prostate cancer (PC) and is associated with AR-regulated ERG overexpression. In castration-resistant PC (CRPC) we found a distinct correlation between TMPRSS2-ERG expression and taxane-resistance depending on treatment sequence. Here, we explore whether TMPRSS2-ERG affects outcomes of patients (pts) with metastatic hormone sensitive PC (mHSPC).

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关键词

prostate cancer,metastatic hormone

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