770P Wild-type BRCA1/2 ovarian cancer: Prospective follow-up data from a multidisciplinary program

BRCA1 and BRCA2 are tumour suppressor genes associated with the hereditary breast and ovarian cancer syndrome (HBOC). Previous data regarding BRCA1/2 penetrance estimated a median cumulative risk of ovarian cancer (OC) by 70 years of 25-40% and 11-18% for BRCA1 and BRCA2 carriers, respectively. In contrast to other populations, HBOC Portuguese patients (pts) have a higher prevalence of BRCA2 mutations, partially due to the effect of the founder BRCA2: c.156_157insAlu. In this study, we analyse the effect on prognosis of BRCA1 and BRCA2 variants in a Portuguese OC cohort.