Two Mixed-Ligand Co(Ii) Coordination Polymers: Treatment Activity On Alzheimer'S Disease By Regulating The A Beta And Inflammatory Response

In the current study, two new Co(II)-bearing coordination polymers (CPs) with solvent induced structural diversity have been successfully prepared via reaction of Co(NO3)(2)center dot 6H(2)O with the 5-methylisophthalic acid (5-H(2)mipa) in the presence of a N-donor co-ligand 1,2-bis(4-pyridyl)ethylene (bpe), and the chemical formulae for the as-prepared CPs are {[Co(5-mipa)(bpe)]center dot 0.4IPA}(n) (1) and [Co(5-mipa)(bpe)](n) (2). Their application values on the Alzheimer's disease treatment were evaluated and the related mechanism was explored at the same time. Firstly, the western blotting assay was performed in this present research for the A beta detection after CP exposure. Besides, the ELISA (enzyme linked immunosorbent assay) detection kit was used to detect the content of the TNF-alpha (tumor necrosis factor-alpha) in the cerebrospinal fluid under CP treatment. Above all, the compound 1 was much better than the compound on Alzheimer's disease.