Convenient Method For Preparing Alpha-Ketoarylthioamide By Air Oxidation Under Base Conditions
CHINESE JOURNAL OF ORGANIC CHEMISTRY(2021)
Abstract
A practical method for preparing alpha-ketoaryl thioamide by air oxidation has been developed. Under air atmosphere, in the presence of K2CO3 as base and dimethyl sulfoxide (DMSO) as solvent at 120 degrees C, a variety of alpha-ketoarylthioamides were obtained from aryl thioamide in yields of 42%similar to 85%. This reaction has good substrate applicability, metal-free and atomic economy, and provides an efficient, economical, green and convenient method for the synthesis of alpha-ketoaryl thioamide.
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Key words
air,dimethyl sulfoxide (DMSO),K2CO3,green oxidation,alpha-ketoaryl thioamide
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