Dapsone Therapy For Hidradenitis Suppurativa: A Retrospective Review Of Characteristics And Treatment Outcomes In 122 Patients In A Tertiary Dermatology Setting Over The Last 6 Years

sample of US inpatients. We analysed cross-sectional discharge data from 2002 to 2014 from the Nationwide Inpatient Sample. We identified patients with HIV and AIDS and 13 IMSDs using International Classification of Diseases, Ninth Revision, Clinical Modification codes. We used SURVEY procedures accounting for discharge trend weights, sample strata and clustering. Strata included hospital census region or division, ownership or control, location, teaching status and number of beds. Summary statistics were calculated using weighted frequencies, means and 95% confidence intervals (CIs). Odds ratios (ORs) and 95% CIs were calculated using multivariate logistic regression. The P-value threshold was adjusted to P < 0 001 to account for multiple comparisons. In total, 101 231 036 discharges were captured during 2002–14. Altogether, 284 035 and 358 180 patients had HIV without AIDS and AIDS, respectively. Patients with HIV and patients with AIDS had mean ages of 48 2 and 47 2 years, respectively, and 36 9% and 31 8% were female, respectively. The most prevalent IMSDs in HIV and AIDS were psoriasis (0 4% and 0 7%, respectively), hidradenitis suppurativa (0 2% and 0 2%, respectively), vitiligo (0 04% and 0 05%, respectively) and atopic dermatitis (0 03% and 0 1%, respectively). Associations between IMSDs and HIV/AIDS were modelled with multivariate logistic regression controlling for age, sex, ethnicity and income. Both HIV and AIDS were associated with higher odds of hidradenitis suppurativa [OR 2 01 (95% CI 1 16–2 56) and OR 2 20 (95% CI 1 80–2 69), respectively] and psoriasis [OR 1 45 (95% CI 1 25–1 69) and OR 2 93 (95% CI 2 72–3 15)]. AIDS was also associated with higher odds of lichen planus (OR 4 25, 95% CI 3 01–6 00), vitiligo (OR 2 97, 95% CI 2 45–3 61), leucocytoclastic vasculitis (OR 2 20, 95% CI 1 59–3 04) and chronic urticaria (OR 1 40, 95% CI 1 16– 1 67). While the association between psoriasis and HIV/AIDS is well established, many other IMSDs have only been linked to HIV/AIDS in case series and reports. Our study provides insight into the burden of IMSD in the US inpatient population and identifies increased odds for hidradenitis suppurativa, lichen planus, leucocytoclastic vasculitis, vitiligo and chronic urticaria in patients with AIDS. In addition, the odds of comorbid psoriasis were higher in those with AIDS than in those with HIV. These findings suggest immunological processes in HIV/AIDS may be related to the development of these IMSDs. O05 Abstract withdrawn.