Protective role of TD0014 against sodium valproate-induced reproductive toxicity in male wistar rats

Sodium valproate (VPA), a common treatment of epilepsy and other diseases, is known to have severe toxic effects on testis both in experimental animals and in humans. This study was carried out to assess the protective activities of the TD0014 against sodium valproate (SVP)-induced reproductive toxicity in male rats. Animals were treated with TD0014 at the dose of 1.8 g/kg/day and 5.4 g/kg/day, and co-administered with SVP (500 mg/kg) for 7 weeks before all reproductive parameters were determined. The results showed all doses of TD0014 significantly protected the decrease testicular weight and testosterone level in SVP rats. TD0014 significantly improved the decrease sperm count and sperm motility in SVP treated rats. Moreover, testicular histology of TD0014 + SVP groups showed declining of testicular histopathologies as compared to SVP group. Therefore, it seems that TD0014 can prevent testicular and spermatozoal damage in male rats induced with SVP. The higher protective effect was seen with TD0014 at 5.4 g/kg dose.